• Users Online: 222
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 3  |  Issue : 1  |  Page : 24-30

Role of endometrial cytokines of the female genital tract tuberculosis in the context of infertility


1 Department of Endocrinology, Institute of Postgraduate Medical Education and Research; Department of Reproductive Medicine, Calcutta Fertility Mission, Kolkata, West Bengal, India
2 Department of Reproductive Medicine, Calcutta Fertility Mission, Kolkata, West Bengal, India
3 Department of Biochemistry, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India

Correspondence Address:
Dr. Siddhartha Chatterjee
Calcutta Fertility Mission, 21, Bondel Road, Kolkata - 700 019, West Bengal
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bjhs.bjhs_1_18

Rights and Permissions

BACKGROUND: Nowadays, one of the most common vulnerable sites of extrapulmonary tuberculosis is female genital tract tuberculosis (FGTB) leading to infertility. As FGTB produce clinical symptom quite late, its detection is very difficult to the health-care providers and according to some experts in this field; FGTB has no confirmatory investigation procedure. FGTB can cause other form of reproductive failure through ectopic pregnancy, tubal block, and implantation failure. Their presence may alter the cytokines level in endometrium. METHODS: A total of 300 cases in our clinic had undergone polymerase chain reaction (PCR) for detection of tubercle bacillus (TB-PCR). Among of them, 91 individuals fulfilling all inclusion and exclusion criteria were included in this study. In our study, we measured cytokines, two from pro-inflammatory group (interleukin-6 [IL-6] and IL-10) and three from inflammatory group (IL-2, interferon gamma [IFNγ], and tumor necrosis factor alpha [TNFα]). RESULTS: Out of 91 participants, 45 (49.46%) cases were TB-PCR positive, and 46 (50.55%) cases were TB-PCR negative. It has been observed that the value of IL-10 and TNFα did not fit any statistical parameter. The result showed that pro-inflammatory indicators IL-6 and inflammatory indicators IL-2 and IFNγ had significant different values between TB-PCR- positive and TB-PCR-negative groups. P value of this cytokines has statistically significant. CONCLUSION: From our study, we conclude that cytokine study was undertaken, of which IFNγ showed a possibility to become an important clinical indicator of endometrial hostility followed by IL-2.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed189    
    Printed10    
    Emailed0    
    PDF Downloaded44    
    Comments [Add]    

Recommend this journal