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Year : 2020  |  Volume : 5  |  Issue : 3  |  Page : 16

Invited Lecture 13: Emerging Role of Nitric Oxide on the occurrence of Metabolic Syndrome and cardiovascular disease

Department of Physiology, HIMSR, Jamia Hamdard, New Delhi, India

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2468-838X.303752

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Brief Biosketch Prof. (Dr) Md Iqbal Alam working as head of the Department of Physiology at HIMSR, Jamia Hamdard, New Delhi. He did his PhD from the University of Calcutta. He was awarded Best Poster in International Conference on Recent Advances in Food fortification with emphasis on Vitamin D in human health, 2018 at Jamia Hamdard, New Delhi., First Prize, best scientific paper awarded in Poster presentation in The inaugural workshop of UNESCO/UNITWIN Network on PhD education and research in Biophysics, Biotechnology and Environmental health. Prof.Iqbal Alam is one of the Coordinators of UNESCO/UNITWIN Network under UNESCO Chair-Life Sciences. He is the author of numerous research publications. Introduction: Metabolic syndrome (MetS) is a complex disorder represented by a cluster of cardiovascular risk factors associated with central fat deposition, abnormal plasma lipid levels, elevated blood pressure, insulin resistance and inflammation. MetS has also been related to increased oxidative and nitrosative stress. High levels of ROS production and reduction in antioxidants lead to endothelial dysfunction characterized by a reduction in the bioavailability of vasodilators, particularly nitric oxide (NO). Materials and Methods: The present study was conducted to delineate the relationship between nitric oxide with the metabolic syndrome developed in High carbohydrate diet (HCD) fed Wistar rats. The relationship was further proven with the help of biochemical and histological studies. Results: After 22 weeks on HCD, rats showed a progressive increase in body weight (obesity) along with dyslipidemia and decreased nitric oxide concentration. The cardiovascular signs included increased systolic blood pressure, left ventricle pressure and endothelial dysfunction together with inflammation, fatty vacuolation, congestion and degeneration of cardiac muscle were found in experimental animals. Conclusion: High carbohydrate diet alone induces metabolic syndrome, and according to our study more effects were seen in rats fed with high carbohydrate diet along with sucrose solution. There was impairment of hemodynamic parameters and increased oxidative stress especially endothelial dysfunction, along with dyslipidemia and inflammation.

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