BLDE University Journal of Health Sciences

REVIEW ARTICLE
Year
: 2021  |  Volume : 6  |  Issue : 1  |  Page : 7--21

Obesity and chronic leptin resistance foster insulin resistance: An analytical overview


Sananda Dey1, Nensina Murmu2, Mayukh Bose3, Shilpi Ghosh4, Biplab Giri1 
1 Department of Physiology, University of Gour Banga, Malda; Experimental Medicine and Stem Cell Research Laboratory, Department of Physiology, West Bengal State University, Kolkata, India
2 Department of Physiology, University of Gour Banga, Malda, West Bengal, India
3 Experimental Medicine and Stem Cell Research Laboratory, Department of Physiology, West Bengal State University, Kolkata, West Bengal, India
4 Department of Biotechnology, University of North Bengal, Darjeeling, West Bengal, India

Correspondence Address:
Prof. Biplab Giri
Department of Physiology, University of Gour Banga, Malda - 732 103, West Bengal
India

Leptin is secreted from adipose tissue, maintains energy balance in our body, and regulates appetite via arcuate nucleus of the hypothalamus. It binds with its receptor (LepR) to kick-start multiple reaction cascades such as Janus kinase 2/signal transducer and activator of transcription 3, suppressor of cytokine signaling-3, insulin receptor substrate 1, phosphatidyl inositol 3-kinase, and protein kinase B-Akt. Insulin increases the uptake of fatty acids and enhances cellular glucose uptake and utilization. Insulin's metabolic effects are mediated by a number of tissue-specific pathways, some of which crosstalk leptin-mediated signaling. Studies showed that leptin resistance is instigated due to the excess release of leptin from adipocytes. It causes a lack of sensitivity toward leptin, for which the body fails to attain satiety and results in more food intake which in turn induces more obesity and aggravates further leptin resistance. Emphasizing on obesity, this review directs toward a possibility of chronic leptin resistance being responsible for insulin resistance. The above statement has been elicited by delineating the point of convergence between insulin and leptin signaling pathways.


How to cite this article:
Dey S, Murmu N, Bose M, Ghosh S, Giri B. Obesity and chronic leptin resistance foster insulin resistance: An analytical overview.BLDE Univ J Health Sci 2021;6:7-21


How to cite this URL:
Dey S, Murmu N, Bose M, Ghosh S, Giri B. Obesity and chronic leptin resistance foster insulin resistance: An analytical overview. BLDE Univ J Health Sci [serial online] 2021 [cited 2021 Jun 19 ];6:7-21
Available from: https://www.bldeujournalhs.in/article.asp?issn=2468-838X;year=2021;volume=6;issue=1;spage=7;epage=21;aulast=Dey;type=0