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  Indian J Med Microbiol
 

Figure 1: Mechanism of leptin resistance. Defects in binding with its receptor, lesion in arcuate nucleus of brain, and increased activity of LRb/signal transducer and activator of transcription 3 contribute to leptin resistance. Leptin can induce suppressor of cytokine signaling-3 and PTB1B, which imply its own resistance as like feedback action. Excess feeding shows unfolded protein response which generates cellular stress and releases stress hormone which produces more leptin leading to resistance. Leptin induces suppressor of cytokine signaling-3 expression which inhibits signal transducer and activator of transcription 3 phosphorylation at the downstream cascade of leptin receptor signaling

Figure 1: Mechanism of leptin resistance. Defects in binding with its receptor, lesion in arcuate nucleus of brain, and increased activity of LRb/signal transducer and activator of transcription 3 contribute to leptin resistance. Leptin can induce suppressor of cytokine signaling-3 and PTB1B, which imply its own resistance as like feedback action. Excess feeding shows unfolded protein response which generates cellular stress and releases stress hormone which produces more leptin leading to resistance. Leptin induces suppressor of cytokine signaling-3 expression which inhibits signal transducer and activator of transcription 3 phosphorylation at the downstream cascade of leptin receptor signaling